Standard (8 weeks) vs long (12 weeks) timing to minimally-invasive surgery after NeoAdjuvant Chemoradiotherapy for rectal cancer: a multicenter randomized controlled parallel group trial (TiMiSNAR)
Articolo
Data di Pubblicazione:
2019
Abstract:
The optimal timing of surgery in relation to chemoradiation is still controversial. Retrospective analysis has demonstrated in the recent decades that the regression of adenocarcinoma can be slow and not complete until after several months. More recently, increasing pathologic Complete Response rates have been demonstrated to be correlated with longer time interval. The purpose of the trial is to demonstrate if delayed timing of surgery after neoadjuvant chemoradiotherapy actually affects pathologic Complete Response and reflects on disease-free survival and overall survival rather than standard timing.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Minimally invasive surgery; Neoadjuvant treatment; Radiation therapy; Rectal cancer; Robotic surgery; TaTME; Timing to surgery
Elenco autori:
Monsellato, Igor; Alongi, Filippo; Bertocchi, Elisa; Gori, Stefania; Ruffo, Giacomo; Cassinotti, Elisa; Baldarti, Ludovica; Boni, Luigi; Pernazza, Graziano; Pulighe, Fabio; De Nisco, Carlo; Perinotti, Roberto; Morpurgo, Emilio; Contardo, Tania; Mammano, Enzo; Elmore, Ugo; Delpini, Roberto; Rosati, Riccardo; Perna, Federico; Coratti, Andrea; Menegatti, Benedetta; Gentilli, Sergio; Baroffio, Paolo; Buccianti, Piero; Balestri, Riccardo; Ceccarelli, Cristina; Torri, Valter; Cavaliere, Davide; Solaini, Leonardo; Ercolani, Giorgio; Traverso, Elena; Fusco, Vittorio; Rossi, Maura; Priora, Fabio; Numico, G; Franzone, Paola; Orecchia, Sara
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