Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract
Articolo
Data di Pubblicazione:
2011
Citazione:
Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract / Monteleone, I; Rizzo, A; Sarra, M; Sica, G; Sileri, P; Biancone, L; Macdonald, T; Pallone, F; Monteleone, G. - In: GASTROENTEROLOGY. - ISSN 0016-5085. - 141:1(2011), pp. 237-248. [10.1053/j.gastro.2011.04.007]
Abstract:
The pathogenesis of inflammatory bowel disease (IBD) is believed to involve an altered balance between effector and regulatory T cells. Aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that mediates the toxicity of dioxins, controls T-cell responses. We investigated the role of AhR in inflammation and pathogenesis of IBD in humans and mouse models.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Animals; Humans; Dextran Sulfate; Interleukins; Disease Models; Animal; Inflammatory Bowel Diseases; Biopsy; Mice; Inbred BALB C; Receptors; Aryl Hydrocarbon; Intestines; Adult; Inflammation Mediators; Flow Cytometry; Time Factors; Signal Transduction; T-Lymphocytes; Carbazoles; Severity of Illness Index; Dose-Response Relationship; Drug; Trinitrobenzenesulfonic Acid; Mice; Basic Helix-Loop-Helix Transcription Factors; Polymerase Chain Reaction; Cells; Cultured; Case-Control Studies; Middle Aged; Up-Regulation; Female
Elenco autori:
Monteleone, I; Rizzo, A; Sarra, M; Sica, G; Sileri, P; Biancone, L; Macdonald, T; Pallone, F; Monteleone, G
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