In vivo confocal microscopy in goldenhar syndrome: a case report

BACKGROUND: Goldenhar Syndrome is characterized by malformations of multiple
anatomical districts. Between these, bulbar dermoids are common and represent a
significant clinical problem as they can affect both ocular function and
aesthetic comfort.Histologic characterization of dermoids has been extensively
performed; however, no reports exist describing in vivo confocal microscopy
(IVCM) of these lesions. We aimed to (i) describe the in vivo confocal morphology
of limbal dermoids in Goldenhar syndrome and (ii) compare these findings with
standard light microscopy.
CASE PRESENTATION: A 15-year-old Caucasian female affected by Goldenhar Syndrome
showed a left, infero-temporal, limbal neoformation, with extension to the left
orbital region. Prior to surgical removal, IVCM was performed with the Heidelberg
Retina Tomograph II, Cornea Module, using the "section" modality. The IVCM
sections showed structures resembling corneal epithelium and vascular structures.
Surgical removal of the lesion was decided as it caused poor eyelid closure.
After surgical removal, sectioning and standard optical microscopy were
performed. The comparison between IVCM imaging and standard microscopy sections
were highly correlated in the detection of the pilar and vascular structures.
CONCLUSIONS: This study showed that IVCM may be a useful technique to study
limbal dermoids, given its ability to detect typical microscopic features and its
comparability to optical microscopy, which is the current standard.