Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: A prospective cohort study
Articolo
Data di Pubblicazione:
2019
Abstract:
Aims: The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). Methods and results: Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. Conclusion: Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
Infective endocarditis; Registry; Valve disease; Adult; Africa, Northern; Aged; Aged, 80 and over; Asia; Community-Acquired Infections; Echocardiography; Embolism; Endocarditis, Bacterial; Enterococcus; Europe; Female; Fluorodeoxyglucose F18; Heart Valve Prosthesis; Hospital Mortality; Humans; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Prospective Studies; Prosthesis-Related Infections; Radiopharmaceuticals; Registries; South America; Staphylococcal Infections; Streptococcal Infections; Treatment Outcome
Elenco autori:
G., Habib; P. A., Erba; B., Iung; E., Donal; B., Cosyns; C., Laroche; B. A., Popescu; B., Prendergast; P., Tornos; A., Sadeghpour; L., Oliver; J. -J., Vaskelyte; R., Sow; O., Axler; A. P., Maggioni; P, Lancellotti; P Gale, C; Beleslin, B; Budaj, A; Chioncel, O; Dagres, N; Danchin, N; Emberson, J; Erlinge, D; Glikson, M; Gray, A; Kayikcioglu, M; P Maggioni, A; K Nagy, V; Nedoshivin, A; Petronio, A-S; Roos-Hesselink, J; Wallentin, L; Zeymer, U; Habib, G; Lancellotti, P; Cosyns, B; Donal, E; Erba, P; Iung, B; P Maggioni, A; A Popescu, B; Prendergast, B; Tornos, P; Andarala, M; Berle, C; Brunel-Lebecq, A; Fiorucci, E; Laroche, C; Missiamenou, V; Taylor, C; N Ali Tatar-Chentir, N; Al-Mallah, M; Astrom Aneq, M; Athanassopoulos, G; P Badano, L; Benyoussef, S; Calderon Aranda, E; M Cardim, N; Chan, K-L; Cosyns, B; Cruz, I; Edvardsen, T; Goliasch, G; Habib, G; Hagendorff, A; Hristova, K; Iung, B; Kamp, O; Kang, D-H; Kong, W; Matskeplishvili, S; Meshaal, M; Mirocevic, M; N Neskovic, A; Pazdernik, M; Plonska-Gosciniak, E; A Popescu, B; Prendergast, B; Raissouni, M; Ronderos, R; E Sade, L; Sadeghpour, A; Sambola, A; Sengupta, S; Separovic-Hanzevacki, J; Takeuchi, M; Tucay, E; C Tude Rodrigues, A; Varga, A; Vaskelyte, J; Yamagata, K; Yiangou, K; Zaky, H; Granada, I; Mahia, M; Ressi, S; Nacinovich, F; Iribarren, A; Fernandez Oses, P; Avegliano, G; Filipini, E; Obregon, R; Bangher, M; Dho, J; Cartasegna, L; L Plastino, M; Novas, V; Shigel, C; Reyes, G; De Santos, M; Gastaldello, N; Granillo Fernandez, M; Potito, M; Streitenberger, G; Velazco, P; H Casabé, J; Cortes, C; Guevara, E; Salmo, F; Seijo, M; Weidinger, F; Heger, M; Brooks, R; Stöllberger, C; Ho, C-Y; Perschy, L; Puskas, L; Binder, C; Rosenhek, R; Schneider, M; Winter, M-P; Hoffer, E; Melissopoulou, M; Lecoq, E; Legrand, D; Jacquet, S; Massoz, M; Pierard, L; Marchetta, S; Dulgheru, R; D Emal, C; Oury, C; Droogmans, S; Kerkhove, D; Plein, D; Soens, L; Weytjens, C; Motoc, A; Roosens, B; Lemoine, I; Rodrigus, I; Paelinck, B; Amsel, B; Unger, P; Konopnicki, D; Beauloye, C; Pasquet, A; L Vanoverschelde, J; Pierard, S; Vancraeynest, D; Sinnaeve, F; L Andrade, J; Staszko, K; Dos Santos Monteiro, R; H Miglioranza, M; L Shuha, D; Alcantara, M; Cravo, V; Fazzio, L; Felix, A; Iso, M; Musa, C; P Siciliano, A; Villaca Filho, F; Rodrigues, A; Vilela, F; Braga, J; Silva, R; Rodrigues, D; Silva, L; Morhy, S; Fischer, C; Silva, R; Vieira, M; Afonso, T; Abreu, J; N Falcao, S; A Moises, V; Gouvea, A; J Mancuso, F; C Souza, A; Y Silva, C; João, G; S Abboud, C; Bellio de Mattos Barretto, R; Ramos, A; Arnoni, R; E Assef, J; J Della Togna, D; Le Bihan, D; Miglioli, L; P Romero Oliveira, A; Tadeu Magro Kroll, R; Cortez, D; L Gelape, C; C Peirira Nunes, M D; C De Abreu Ferrari, T; Hay, K; Le, V; Page, M; Poulin, F; Sauve, C; Serri, K; Mercure, C; Beaudoin, J; Pibarot, P; A Sebag, I; G Rudski, L; Ricafort, G; Barsic, B; Krajinovic, V; Vargovic, M; Lovric, D; Reskovic-Luksic, V; Vincelj, J; Jaksic Jurinjak, S; Yiannikourides, V; Ioannides, M; Pofaides, C; Masoura, V; Pudich, J; Linhart, A; Siranec, M; Marek, J; Blechova, K; Kamenik, M; Pelouch, R; Coufal, Z; Mikulica, M; Griva, M; Jancova, E; Mikulcova, M; Taborsky, M; Precek, J; Jecmenova, M; Latal, J; Widimsky, J; Butta, T; Machacek, S; Vancata, R; Spinar, J; Holicka, M; Pow Chon Long, F; Anzules, N; Bajana Carpio, A; Largacha, G; Penaherrera, E; Moreira, D; Mahfouz, E; Elsafty, E; Soliman, A; Zayed, Y; Aboulenein, J; Abdel-Hay, M; Almaghraby, A; Abdelnaby, M; Ahmed, M; Hammad, B; Saleh, Y; Zahran, H; Elgebaly, O; Saad, A; Ali, M; Zeid, A; El Sharkawy, R; Al Kholy, A; Doss, R; Osama, D; Rizk, H; Elmogy, A; Mishriky, M; Assayag, P; El Hatimi, S; Hubert, S; Casalta, J-P; Gouriet, F; Arregle, F; Cammilleri, S; Tessonnier, L; Riberi, A; Botelho-Nevers, E; Gagneux-Brunon, A; Pierrard, R; Tulane, C; Campisi, S; Fuzellier, J-F; Detoc, M; Mehalla, T; Boutoille, D; S Lecompte, A; Lefebvre, M; Pattier, S; Al Habash, O;
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