Design, synthesis and biochemical investigation, by in vitro luciferase reporter system, of peptide nucleic acids as new inhibitors of miR-509-3p involved in the regulation of cystic fibrosis disease-gene expression
Articolo
Data di Pubblicazione:
2014
Citazione:
Design, synthesis and biochemical investigation, by in
vitro luciferase reporter system, of peptide nucleic acids
as new inhibitors of miR-509-3p involved in the
regulation of cystic fibrosis disease-gene expression / Amato, Felice; Tomaiuolo, Rossella; Borbone, Nicola; Ausilia, Elce; Amato, Jussara; D'Errico, Stefano; DE ROSA, Giuseppe; Mayol, Laura; Piccialli, Gennaro; Oliviero, Giorgia; Castaldo, Giuseppe. - In: MEDCHEMCOMM. - ISSN 2040-2503. - 5:1(2014), pp. 68-71. [10.1039/C3MD00257H]
Abstract:
Recently, microRNAs (miRNAs) were identified able to inhibit the expression of the Cystic Fibrosis Transmembrane Regulator (CFTR) disease-gene of Cystic Fibrosis (CF) and CFTR-Related Disorders (CFTR-RD). This study shows the use of peptide nucleic acids (PNAs) as inhibitors of miR-509-3p, one of the CFTR regulating miRNAs, by reverting the expression of luciferase gene containing the 3 'UTR of CFTR gene.
Tipologia CRIS:
1.1 Articolo in rivista
Keywords:
TRANSMEMBRANE CONDUCTANCE REGULATOR; PNA; DNA; OLIGONUCLEOTIDES; HYBRIDIZATION; MICRORNAS; GENE
Elenco autori:
Amato, Felice; Tomaiuolo, Rossella; Borbone, Nicola; Ausilia, Elce; Amato, Jussara; D'Errico, Stefano; DE ROSA, Giuseppe; Mayol, Laura; Piccialli, Gennaro; Oliviero, Giorgia; Castaldo, Giuseppe
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